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Role of Calcium and Magnesium Infusion in Prevention of Oxaliplatin Neurotoxicity

1 Introduction Lung cancer is among the most prevalent and lethal cancers worldwide, accounting for a significant proportion of all cancer-related deaths ( lncRNAs are RNA molecules exceeding 200 nucleotides in length and do not code for proteins ( GSH is a crucial intracellular antioxidant composed of glutamic acid, cysteine, and glycine ( Through the analysis of TCGA dataset, this research has identified long lncRNAs related to GSH metabolism and has developed a new type of risk assessment model accordingly

The rate of GSH depletion was found to be higher on d5 compared to d14

Nevertheless, in breast cancer and lung cancer cells, paclitaxel activates AMPK, inhibits mTOR signaling and increases apoptosis (Rocha et al., 2011)