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Wright and Harding, 2019)

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33,34,35,36 Similarly, 73% of trials excluded patients with systemic or local infection

Activated microglia produced inflammatory mediators, such as prostaglandin E 2 , interleukin-1 TNF, ROS (peroxideH 2 O 2 , superoxideO 2 ), and reactive species nitrogenous (RNS: NO

195,196 Specifically, treatment with DSF and Cu could decrease expression of the tumor suppressor gene PTEN and activate AKT signaling in human breast cancers, providing a rationale for testing combination therapies using Cu ionophores and PI3K-AKT inhibitors in future studies