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Nutrients, 12 (12)

Protein identification and quantification global proteomics Resulting MS2 RAW files were analyzed in Proteome Discoverer 2.5 (Thermo Fisher Scientific) with FASTA databases including UniProt human sequences plus common contaminants such as proteolytic digestion enzymes

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We show that zonulin is a central factor in this process as it disrupts intestinal TJ proteins, enhances intestinal permeability and leads to Th1 and Th17 infiltration in the lamina propria before the onset of murine and human arthritis
CagriSema leans on two better-understood metabolic signals
