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short 2.5 mg cohort about -4.7% at ~4 weeks, -12.7% by the 5 mg phase (Barrea 2026): Mody Diabetes Ther 2025
The researchers thus hypothesized that blocking NNMT could open a novel path to treating obesity and its metabolic complications [1, 2]
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This blocks the cAMP-dependent pathway that promotes H+K+-ATPase function, thus reducing gastric acid production
