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The cobalt of cobalamin can exist in three oxidation states, +1 [cob(I)alamin], +2 [cob(II)alamin], and +3 [cob(III)alamin]

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Treatment of newborn rats with L-buthionine sulfoximine (BSO), an irreversible inhibitor of GCLC, leads to hepatic abnormalities including mitochondrial dysfunction 10