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J.CreeI
Lipid nanoparticles-rom liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement
Transpl Immunol (2015) 32(1):4650
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ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis
