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In cholangiocarcinoma, combined BET degradation and mTOR inhibition synergistically reduce acetylation of PSAT1-associated H3K27, inducing PSAT1 downregulation and subsequent dysfunction of the serine-glycine-one-carbon (SGOC) pathway (114)
Genetic variants of AGXT (alanine glyoxylate aminotransferase) gene coding for alanine glyoxylate aminotransferase (i.e., an enzyme involved in oxalate metabolism) have been correlated with the severity of CIPN in patients on oxaliplatin therapy [26]
COAs are documents that verify that a supplement or material has undergone testing and meets specific quality standards
