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In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]
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however, short-term beef provocation did not cause plasma L-Cn levels fluctuation, which suggested L-Cn as a potential stable plasma biochemical marker ( Supplementary Figures 2C, D )
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