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This article explores key ligands that can enhance blood-brain barrier crossing of agar-based nanoparticles, including transferrin, lactoferrin, Angiopep-2, and glutathione, along with design strategies for improved brain delivery.

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A literature search was conducted from January 2000 to December 2022 using multiple databases including Web of Science, Wiley, Springer, PubMed, Elsevier Science Direct, Google Scholar, the Core Collection, Scopus, and the Cochrane Library to collect and evaluate peer-reviewed literature regarding the neuroprotective role of metformin against DM-induced neurodegenerative events

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