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Furthermore, oxaliplatin induced neuropathy may be exacerbated by surgery (Gornet et al., 2002)
Oxygen radicals as key mediators in neurological disease: fact or fiction
[DOI] [PubMed] [Google Scholar] Ip P, Wong V, Ho M, Lee J, Wong W
Hou W, Xie Y, Song X, Sun X, Lotze MT, Zeh HJ 3rd, et al
During iron scarcity, the IRE-IRP system also downregulates proteins associated with iron usage [37], including the haem synthesis protein, 5-aminolevulinic acid synthase (ALAS)-2 [38], and the tricarboxylic acid (TCA) cycle enzyme, mitochondrial aconitase 2 (ACO2), which requires a [2Fe-2S] cluster for catalysis [39]
