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NLRP3 inflammasome-mediated pyroptosis involvement in cadmium exposure-induced cognitive deficits via the Sirt3-mtROS axis

doi: 10.1007/s00403-025-04137-7 Sharma Bharti

In those suffering from narcolepsy, a rare disorder where the brain cannot regulate the normal sleep cycle, LC treatment promoted daytime wakefulness

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Although these results might appear contradictory, they can be reconciled by our histological findings showing a reduction of intracellular/somatic GABA signal at P12, particularly in layer 5, consistent with the selective vulnerability of output-layer circuits rather than pan-cortical degeneration, as GABAergic neuron numbers were relatively maintained across other layers
