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JAMA, 2014

Rnf43/Znrf3 can ubiquitinate FZD, inducing FZD endocytosis and resulting in the downregulation of Wnt signalling

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Thus, the clinical threshold for nephrotoxicity is determined by the balance between the rate of necrosis and the rate of regeneration of proximal tubular cells (Soberon et al., 1979)

Caspase-3 activation after neonatal rat cerebral hypoxia-ischemia
