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Acta Pharmacol Sin 41:471482

Vitamin B12 is bound to intrinsic factor during transit through the stomach

Loading Phase (Weeks 1-4): 2 to 2.5 mg twice weekly (Monday/Thursday schedule) Maintenance Phase (Weeks 5+): 2 mg once every 7 to 14 days Administration: Subcutaneous injection, location flexible due to systemic distribution Total Cycle: 8 to 12 weeks with 4 to 8 weeks off between cycles The convenience of twice-weekly dosing during loading and weekly or biweekly dosing during maintenance fits easily into Retatrutide schedules

Reconstitution and storage follow standard peptide protocols

An implementation in this direction would make it possible to answer relevant scientific questions