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And while white sugar, caffeine, dairy and chemical-laden makeup are the most common skin saboteurs, research suggests too much of a certain vitamin may also be causing your breakouts: vitamin B12 (1)(2)

There is around a 2.5-fold increase in B12 deficiency incidence in those treated with metformin, and this may occur as early as 3 months, although hepatic stores of vitamin B12 may take 5 years or more to deplete (Bell, 2022)

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Several explanations have been proposed for the discrepancy between the two trials