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2013 meta-analysis: A meta-analysis of 13 clinical trials including 3,629 adults with acute myocardial infarction who took L-carnitine (from 2.7 g/day for 5 days to 6 g/day for 12 months) versus placebo found that L-carnitine significantly reduced rates of all-cause mortality, ventricular arrhythmias, and new-onset angina

Cave MC, Hurt RT, Frazier TH, Matheson PJ, Garrison RN, McClain CJ, McClave SA: Obesity, inflammation, and the potential application of pharmaconutrition

These findings suggest that the efficacy of GLP-1RA-based anti-obesity treatments may be contingent upon carnitine bioavailability, particularly in populations with restricted dietary intake (e.g., vegans) who rely heavily on the de novo biosynthetic pathway, while also positioning SLC25A45 as a transcriptionally regulated target of thyroid hormone-mediated metabolic adaptation

Di Fermo P, Di Lodovico S, Di Campli E, et al

Symptoms of SFN include heightened pain sensitivity, abnormal sweating, and restless legs