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Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer

Wang F, Zhang C, Zhu X, Zhang D, Zhang Z, Ni S, Wang Z, Xu S, Lan X, Ding Y, Liang L (2022) Overexpression of GSTP1 promotes colorectal cancer cell proliferation, invasion and metastasis by upregulating STAT3

This point supports the opposite effect of L-arginine and in addition, the evidence that when given together, L-NAME + L-arginine could antagonize each others response

Common in peptide protocols, 4-8 weeks intensive loading followed by reduced maintenance

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