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First, the preponderance of data arises from laboratory assays, such as broth microdilution and biofilm inhibition tests, that, although invaluable for elucidating mechanistic insights, cannot fully reproduce the complex interplay of host immunity, tissue distribution, and pathogen virulence encountered in living organisms

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The review also addresses current clinical approaches to the management of AAS-related complications, including strategies aimed at hormonal recovery and restoration of reproductive function

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