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In the brain, endogenous GDF11 may have different functions depending on region, and exogenous GDF11 does not appear to appreciably penetrate the uninjured blood-brain barrier
doi:10.3389/fnut.2022.882309
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Generally, women in midlife take oral progesterone at bedtime, especially when it's prescribed as part of hormone replacement therapy (HRT, now commonly referred to as menopause hormone therapy, or MHT)
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