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Because the polarized-M2 phenotype of macrophages affects tumor growth, invasiveness, angiogenesis (140), and GSK 3 has been reported to enhance the polarization of microglia toward M2 (141), GSK 3 may be the potential therapeutic target for cancer immunotherapy

The Hy-NO-Ag-Cip minimum inhibitory concentration (MIC) was 250 g/mL, and the 2 MIC of this hydrogel reduced mature biofilm by 65%

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T cells require glutamine to proliferate and secrete the effector cytokines IL-2 and IFN, but glutamine is not required for the expression of early activation markers, such as CD25, CD69, and CD98 [144]