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The frequency of these injections can vary from daily to monthly, depending on how severe the deficiency is and how well the patient responds

[44] Neomycin: Absorption of vitamin B-12 can be reduced by neomycin, but prolonged use of large doses is needed to induce pernicious anemia

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Allen Press, Lawrence Angeleri F, Marchesi GF, Quattrini A (1969) Effects of chronic thalamic lesions on the electrical activity of the neocortex and on sleep