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The corresponding mouse PrP variants (G53S or M128V) were transfected into ATP7B-KO HepG2 cells with stable PRNP knockdown

Certain muscle groups observed in murine models, including the rectus abdominis, psoas major , and paraspinal muscles, showed a more pronounced increase in muscle density and volume, as well as a reduction in intramuscular fat content, than those observed in controls

Cox MA, Bassi C, Saunders ME, Nechanitzky R, Morgado-Palacin I, Zheng C, et al