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Patients with Leber hereditary optic neuropathy should not take methyl B12, since this disease can get worse with high methyl B12 levels
M.AbdonB.MattiolaZ.KlaissA.et al (2025)

Dempsey TM, Payne S, Sangaralingham L, et al
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Approved vaccines against hepatitis B virus (HBV), human papillomavirus (HPV), and hepatitis E virus (HEV) exemplify the capacity of VLP-based platforms to induce durable and protective immunity (Zhu et al., 2010)
