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Treatment is limited for most IEMs and is often based on reducing the accumulation of toxic metabolites through substrate restricted diets, cofactor supplementation, specific therapies to facilitate urinary excretion and enzyme replacement
How LRU Works: The Basics The Least Recently Used (LRU) cache replacement policy is based on the principle that items that have been accessed recently are more likely to be accessed again in the near future
Depending on the pH of the medium in which it is located, ascorbic acid may lose the hydrogen ions attached to one of its two ionizable groups located at carbons 2 and 3, generating ascorbate monoanion or dianion (Tolbert et al., 1)
It is still unknown if differences in CD81 usage by the T/F variants could contribute to different clinical outcomes
