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After a thorough analysis of the information acquired on the immunomodulatory properties of the Zingiber and Alpinia species, future research directions and pertinent prospects for the bioactive metabolites as potential candidates for the development of new natural immunomodulating agents were highlighted

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additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81