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Another pathognomonic feature of LAL-D is birefringent cholesterol ester crystals in hepatocytes and Kupffer cells, using polarized light on electron microscopy

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In addition, many flavonoids exert actions on different molecular pathways related to glycaemia but also exert antioxidant, anti-glycaemic, and anti-inflammatory actions, making them bioactive compounds of interest in the management and prevention of metabolic complications related to hyperglycaemia

The secondary structure composition of free and immobilized CRL is listed in the Table 3

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