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Pesticides and other agricultural or industrial chemicals further exacerbate oxidative stress by disrupting redox-sensitive signaling pathways and impairing antioxidant defense mechanisms
Thus, ROS production, caused by AFs, drives immune cells to prooxidant/inflammation status, such as autophagy and extracellular trap formation in macrophages, through TLRs (59)
The level of DNA damage and mutations varies significantly across different cell types, tissues, and individuals, shaped by intrinsic differences in genomic maintenance mechanisms and the impact of environmental factors
2008) but not in microglial cultures (Trang et al
