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Golan A, Weissman A

Notably, the majority of valerolactone in urine existed in conjugated forms, suggesting that microbial-derived metabolites, once absorbed, undergo host phase II modification before renal clearance

10.1186/s10020-024-00873-0 294 LuL.LiW.SunC.KangS.LiJ.LuoX.et al

51, 74, 75, 76, 77, 78 The molecular mechanisms that underlie the cytotoxic potential of cytoplasmic CDDP are poorly understood, yet may involve: (i) the accumulation of reactive oxygen species (ROS) and nitric oxide (NO), which not only exacerbate CDDP genotoxicity but also exert direct cytotoxic effects by favoring the opening of the so-called permeability transition pore complex (PTPC)