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Experts believe that Alzheimer's dementia, like other common chronic diseases and conditions, develops as a result of multiple factors rather than a single cause

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Pihan G, Majzoubi D, Haudenschild C, Trier JS, Szabo S

Am J Phys Heart Circ Phys 304:H1085H1093 Wu FT, Stefanini MO, Mac Gabhann F, Kontos CD, Annex BH, Popel AS (2010) VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model

Even minor usage can cause adverse effects, such as: Muscle pain Dry mouth Anorexia and/or weight loss Chills Nausea and vomiting Constipation Liver damage Dizziness Insomnia Hallucinations Seizure While human data on 7-OH is limited, its potency suggests dependence risk could be even higher than kratoms