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This suggests that a glycocalyx (glypican, heparan sulfate)-caveolae-eNOS pathway plays a major role in the mechanosensation and mechanotransduction response to physical deformation in endothelial cells (57)

MOTS-C works by activating the AMP-activated protein kinase (AMPK) pathway, a central energy-sensing mechanism that promotes glucose uptake, fatty acid oxidation, and insulin sensitivity

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