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Impaired autophagy, oxidative stress, and reactive oxygen species Accumulation of Gb3 in lysosomes interferes with the autophagic process (76), leading to the accumulation of damaged organelles including mitochondria (77) and protein aggregates, triggering inflammation
A.KnoblichJ
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hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase
Clinical activity of a htert (vx-001) cancer vaccine as post-chemotherapy maintenance immunotherapy in patients with stage IV non-small cell lung cancer: final results of a randomised phase 2 clinical trial
