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When you stop supplementing, your body does not experience a "crash," but it does return to its natural baseline levels

Adams and McCue demonstrated that localized IGF-1 overexpression in mouse hindlimb muscles produced significant increases in muscle mass, with satellite cell contribution essential to the hypertrophic response (Adams & McCue, 1998)

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Similarly, in vitro treatment of vitamin E deficient medium resulted in GPX4 knockout endothelial cell ferroptosis