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Plant Physiol 123:12891300 Verberne MC, Hoekstra J, Bol JF, Linthorst HJM (2003) Signaling of systemic acquired resistance in tobacco depends on ethylene perception

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HYGIENE A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS A61P33/00Antiparasitic agents AHUMAN NECESSITIES A61MEDICAL OR VETERINARY SCIENCE

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Every experiment was repeated at least three times, and representative data are shown

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The reasons for these failures often include short in vivo half-life, chemical instability, limited cellular uptake, poor bioavailability, lack of targeted delivery to specific tissues or (sub)cellular compartments, a narrow therapeutic index, and toxicity

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