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Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

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Interestingly, while this study discovered that CHAC1/BOTCH-mediated regulation of GSH levels controls development, other studies suggest its developmental role is primarily based on the inhibition of NOTCH1 signaling (Yadav et al., 2019)

10.1093/jxb/erv073 16 CriquiM

It was noted that although nebulized NAC did not show superior results than normal saline in reducing density of mucus plugs in mechanically ventilated patients, mean secretion density was significantly lower in the NAC group (P=0.006) and NAC increased O 2 saturation significantly (P=0.014)