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Pralatrexate: 1 (milligram) mg of vitamin B12 as an injection no more than 10 weeks prior to the first dose and every 8 to 100 weeks thereafter

Risks and Side Effects While generally safe, vitamin B12 injections can have side effects or risks, such as: Mild pain, swelling, or redness at the injection site Dizziness, headache, or nausea Allergic reactions (rare) Hypokalemia (low potassium levels) in individuals with severe deficiency undergoing treatment People with allergies to cobalt or who have Lebers disease should avoid B12 injections unless specifically advised by a doctor

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