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Subcutaneous once weekly

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Osteoarthritis Pain Relief The December 2025 phase 3 data reported a finding that has received little coverage relative to the weight loss headline: substantial relief from osteoarthritis pain

Typically mild and improves over 1-2 weeks at each dose level Constipation : Tirzepatide slows gastric emptying, which can reduce bowel movement frequency Diarrhea : Some patients experience the opposite problem, particularly at higher doses Headaches : Common in the first week or two, usually resolving on their own Fatigue : Especially during early treatment when caloric intake drops significantly Injection site reactions : Redness, itching, or mild swelling at the injection site Dry mouth : A less discussed but fairly common side effect Muscle pain : Some patients report muscle aches, particularly during dose escalation Anxiety : Less common but reported by some patients VitaStir reviewers consistently mention that side effects are manageable