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Our observation that CR fails to decrease liver Nr1d1 mRNA expression in Gcgr KO mice at both 6 and 17 months of age is in line with these findings (Supplemental Figures L&P)

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sFRPs have a Netrin-related motif in the C-terminal region, WIF has a WIF domain in the C-terminal region, and both bind to Wnt proteins, thereby inhibiting Wnt signalling
