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Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1

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So the body utilizes only about 1% of BCAAs to build new protein, with the remaining 99% being converted to calories

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Vascular Dysfunction : Compromise of the blood-brain barrier integrity leads to impaired nutrient and oxygen supply, contributing to neuronal dysfunction

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Face mask anesthesia (12% isoflurane in 70/30% nitrous oxide/oxygen) was used during the entire procedure

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While dietary therapy with ornithine supplementation and restriction of protein or arginine intake can help reduce the accumulation of neurotoxic guanidinoacetic acid and achieve a good improvement in the dyskinesia manifestations associated with CDDS2 [42]

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