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Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases

presumably acetyl-CoA would still be needed for histone acetylation and the mevalonate pathway even if fatty acid synthesis activity is low

It has been shown that prolonged use of statins may induce the development of ALS-like syndrome and may increase ALS risk

Because KAT6A contains multiple functional domains, it is possible that ARTHS variants may result in a truncated protein that retains acetyltransferase activity but lacks proteinprotein interaction domains that regulate this activity

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