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Description
Although rare, adverse effects of high-dose vitamin B12 have been reported, including allergic reactions such as fever, rash, itching, hot flushes, dizziness, and nausea, across all cobalamin forms and administration routes (Caballero et al., 2007)

A deficiency can lead to a type of anemia called megaloblastic anemia, causing fatigue and weakness

Common oral protocols deliver 50 to 150 mg per day, typically dosed once or twice daily with food

These findings were shared at a major medical conference (EASD) in September 2025

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