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Zhou Z, Xu J, Zhao Y, Niu Y

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

When lipids and carbohydrates are consumed, K cells in the duodenum and jejunum release glucose-dependent insulinotropic polypeptide (GIP) (185190)

Science 322 , 15111516 (2008)

Later REDEFINE trial programme obesity data summarised in 2025 reported up to 22.7% reduction at 68 weeks, though full peer-reviewed publication remains limited [6]
