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These mechanisms involve serotonin transmission (1315), the generation of new neurons (neurogenesis) (16, 17), and protection against excitotoxic damage (18)

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Dashed lines represent 95 % confidence intervals

The extended half-life of IGF-1 LR3 (2030 hours vs 10 minutes for endogenous IGF-1) makes it suitable for research protocols requiring sustained receptor activation, but the same structural modifications increase susceptibility to denaturation during handling