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10.1016/j.taap.2017.09.021 3 Abu-RishaS

Effects of N-acetylcysteine and metformin treatment on the stereopathological characteristics of uterus and ovary

Symptoms of estrogen dominance in women In women, estrogen dominance is associated with a huge array of debilitating symptoms, including: Recurring PMS Weight gain, particularly around the tummy, hips, and thighs Fibrocystic breasts Fibroids Endometriosis Irregular menstrual cycle Low energy and/or fatigue Reduced sex drive Low mood or depression Anxiety Bloating Breast tenderness Mood swings Brain fog Sleeping problems and/or insomnia Estrogen dominance is also linked to much more serious long-term health conditions
Finally, we show that GSH synthesis in the liver suppresses the activity of the antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2)

Drug Discov Today Ther Strateg 10:e21e24
