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No established upper limit exists because excess b12 excretes through kidneys without causing harm

Martinez-GurynKHubertNFrazierKUrlassSMuschMWOjedaPet alSmall intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids

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This makes them suitable for a proof-of-concept trial: there is real variation to detect, and a real-world population that would benefit from better intervention options
