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Advanced stage , where cartilage has completely eroded, causing bone-on-bone friction, joint deformity, muscle atrophy, and chronic synovitis

These two C-shaped wedges of fibrocartilage sit between your femur (thighbone) and tibia (shinbone), acting as critical shock absorbers and stabilizers

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Current treatment options include approved drugs such as serotonin-norepinephrine reuptake inhibitors, e.g., duloxetine, gabapentinoids such as pregabalin and gabapentin, topical treatment with capsaicin, and several off-label use drugs such as other antidepressants (e.g., tricyclic antidepressants), antiepileptic drugs, and weak and strong opioids