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Fang Y, et al

As a retrograde signaling molecules, mitochondrial-released ROS induce the activation of intracellular redox-related signaling pathways, such as those involving NRF2/Keap1, forkhead box O proteins (FoxOs), heat shock factors, or antioxidant enzymes such as peroxiredoxin 2, promoting an adaptive response aimed at protecting the cells from further damage (Ristow, 2014

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In a 2022 study on vitamin B12 deficiency in overt and subclinical hypothyroidism, researchers found that the rates of vitamin B12 deficiency are higher in patients with hypothyroidism compared to the general population

Definitive conclusions regarding therapeutic efficacy, optimal dosing, and long-term safety will require larger, longer-term randomized trials with clinically meaningful endpoints