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At the same time, MOTS-c elevates cellular NAD levels and engages sirtuin pathways (e.g SIRT1), which are well-known longevity and metabolic regulators
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On the other hand, it is not advised to use these drugs for a long-term since the protein expressions of CYP isozymes involved in steroidogenesis as well as the numbers of spermatocytes in testes were decreased.
To address this, we developed a method for the rapid immunopurification of the ER, enabling comprehensive profiling of its proteome and metabolome
