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The Franklin is funded through the UK Research and Innovation through the Engineering and Physical Sciences Research Council (EPSRC)
21 (Suppl 3): S3S6
[DOI] [PubMed] [Google Scholar] 104.Cobbina E., Akhlaghi F
The released ROS activate the ion channel TRPM2 in macrophages, promoting calcium influx, thereby eliciting an immune response
This insufficient targeting leads to low NADs concentrations at the disease site and unintended gene silencing or activation, potentially causing safety issues by requiring higher doses
