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It occurs naturally in human plasma, declining from ~200 ng/mL in young adults to ~80 ng/mL with age

discussion 814-6

The majority of back pain cases stem from disc issues, facet joint problems, ligament damage, or a combination of factors

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Therefore, we measured ROS production in HCT116 GSTA4 cells compared with that in HCT116 cells and found that inactivation of GSTA4 increased ROS production in untreated HCT116 GSTA4 cells in contrast to HCT116 cells
