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GSH production is supported by NRF2 through controlling several enzymes responsible for GSH synthesis, such as the glutamate-cysteine ligase (GCL) complex composed of two subunits, the modifier (GCLM) subunit and the catalytic (GCLC) subunit, which catalyze the rate-limiting step of GSH synthesis that converts cysteine and glutamate into GSH [22]

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Rogers JT, Randall JD, Cahill CM et al (2002) An iron-responsive element type II in the 5-untranslated region of the Alzheimers amyloid precursor protein transcript

The role of mitochondria in reactive oxygen species metabolism and signaling

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