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Because vitamin B 12 in supplements is not bound to protein, and because intrinsic factor (IF) is still available, the absorption of supplemental vitamin B 12 is not reduced as it is in pernicious anemia

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[DOI] [PMC free article] [PubMed] [Google Scholar] 235.Wei C-C et al

Several human clinical trials are ongoing to assess the safety and efficacy of NAD + augmentation (TABLE 2) and, importantly, early-phase trials of short-term NR/NMN administration have proven it to be safe and to increase NAD + levels in healthy participants